Since the skin is the largest organ of the human body and is physiologically intimately associated with the other structures which it protects by way of the nerves, blood vessels, and interchange of secretions from the glands within itself as well as the endocrine glands, it has long been known as an excellent mirror of both normal and pathologic states. Its normal functions are those of protection, heat regulation, secretion, and excretion, which it performs with a high degree of efficiency. Any gross deviation of the normal functions of the skin is quite immediately apparent, with varying symptoms referable to the skin and the appearance of various dermatologic lesions. In addition, many obscure and deep-seated pathologic processes such as endocrinopathies, metabolic disorders, systemic intoxications, hematologic diseases and neoplastic diseases, disorders of the nervous system, collagen disorders, infectious diseases, and disorders of the liver and biliary tract may have dermal components,
DUEMLING WW, NORMAN CW. Mucocutaneous Changes: Manifestations of Blood Dyscrasias and Hemorrhagic Disturbances. Arch Dermatol. 1961;84(2):273–289. doi:10.1001/archderm.1961.01580140099013
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