Erythema nodosum associated with tuberculosis has not been noted frequently in the United States.1 Beerman2 stated that American dermatologists believe erythema nodosum occurs in 2 forms—a disease entity per se, frequently associated with hilar adenopathy which clears when the cutaneous lesions disappear, and a symptomatic form which is secondary to streptococcal infections, dermatitis medicamentosa (sulfonamides, iodides, and bromides), sarcoidosis, coccidioidomycosis, lymphogranuloma venereum, and occasionally tuberculosis or other granulomas.
In Scandanavia, however, tuberculosis has been accepted as a major etiological factor of erythema nodosum. Lofgren3 found that 58% of his patients had active tuberculosis. Most of these patients ranged in age from 15 to 24 years. Similarly, reports from the British literature show a frequent relationship between erythema nodosum and tuberculosis. Simpson,4 in 1950, stated that 75% of the cases in temperate climates were found in tuberculous patients. Lorber,5 in 1950, noted that tuberculosis was becoming
HELDEMAN MD, SKOLNICK M. Erythema Nodosum and Pulmonary Tuberculosis in Two Sisters: Report of a Case. Arch Dermatol. 1961;84(3):402–403. doi:10.1001/archderm.1961.01580150048008
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