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September 1961

Cyclic Neutropenia

Author Affiliations


From the Department of Dermatology, School of Medicine, University of Pennsylvania.

Arch Dermatol. 1961;84(3):429-433. doi:10.1001/archderm.1961.01580150075012

Cyclic neutropenia is an unusual disease with numerous dermatologic manifestations. It was first reported in 1910 by Leale,1 and Löblowitz,2 who described the characteristic cyclic recurrence of oral ulcerations. They also noted the presence of an abnormal white blood cell count in their patients, but did not correlate this finding with the occurrence of mouth lesions. Thereafter there were numerous published reports of periodic oral ulcerations; however, the synchronous recurrence of neutropenia again was not investigated. It was not until 1930 that a definite association was established3 between the neutropenia and the mouth ulcerations, both of which recur along with fever, malaise, arthralgia, etc. at regular intervals of 21 days. There have been 32 additional case reports of cyclic neutropenia, with the majority appearing after 1946.

Despite the extensive ulcerations of the lips, tongue, palate, gums, and buccal mucosa, as well as other cutaneous manifestations, dermatologists generally

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