[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address 34.237.138.69. Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Article
September 1961

Nature and Incidence of Photosensitivity Reactions to Demethylchlortetracycline

Author Affiliations

PHILADELPHIA; PEARL RIVER, N. Y.

From the Department of Dermatology, School of Medicine, University of Pennsylvania (Dr. Cahn and Dr. Levy), and Lederle Laboratories, Research Division (Dr. McMillen).

Declomycin, Lederle Laboratories, Pearl River, N.Y.

Arch Dermatol. 1961;84(3):485-489. doi:10.1001/archderm.1961.01580150131022
Abstract

Several recent case reports1-3 have indicated the occurrence of photosensitivity reactions in patients taking demethylchlortetracycline.* This study was undertaken to determine the incidence of such reactions, the relationship between their occurrence and dosage of the drug, the responsible spectral range, and the nature of these reactions, whether photoallergic or phototoxic.4

Method 

I. Determination of Incidence of Demethylchlortetracycline Photosensitivity Reactions.—  (A) Using Artificial Light Sources: One hundred white men, who had not been exposed to sunlight for the preceding 6 months were included in this phase of the study. The minimal erythema dose (M.E.D.), which is defined as that amount of ultraviolet light required to produce a barely perceptable erythema on the skin 24 hours after exposure (1+) was determined for each subject. This was accomplished by giving graded exposures of ultraviolet light to skin test sites on the upper back, as emitted by a Westinghouse fluorescent

×