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September 1961

Epidermolysis Bullosa Hereditaria Treated with Antimalarials

Author Affiliations


Assistant Clinical Professor of Dermatology, University of Pittsburgh.

Arch Dermatol. 1961;84(3):503-504. doi:10.1001/archderm.1961.01580150149026

The antimalarial drugs have been found to be useful in the treatment and arrest of chronic discoid lupus erythematosus, the light sensitive dermatoses, rheumatoid arthritis, and other of the so called "collagen diseases." Although the method of action is unknown, current case reports reveal that this group of drugs is being used in many other disease entities whose etiology is both known and unknown.

The following reports of 2 patients with epidermolysis bullosa hereditaria and their clinical response to antimalarial therapy suggests another use for these drugs. A careful search of the literature for the past 10 years reveals no previous report of the use of antimalarial drugs in the treatment of any type of congenital dermatosis.

Case 1.—  A white female, age 19 years, presented herself with a history of recurrent blisters and ulcers on the exposed portions of the body— face, neck, arms, forearms, hands, legs, and dorsa of