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October 1961

Inheritance of Psoriasis in a Utah Kindred

Author Affiliations


Assistant Professor of Medicine, Department of Internal Medicine, University of Utah College of Medicine (Dr. Ward). Emeritus Professor of Biology, Laboratory of Human Genetics, University of Utah (Dr. Stephens).

Arch Dermatol. 1961;84(4):589-592. doi:10.1001/archderm.1961.01580160053006

Psoriasis is a chronic inflammatory skin disorder of unknown etiology and inconstant course which constitutes about 6% of all new skin cases seen by dermatologists.1 Of interest is the association of arthritis and psoriasis. This arthritis is characterized by absorptive phenomena usually of peripheral joints and has been considered to be a distinct form of joint disease.2,3 The familial occurrence of psoriasis is well known and studies have described the inheritance as recessive, double recessive, and irregular dominant. Schamberg4 reviewed 592 patients with psoriasis and reported a family occurrence of 13%. He concluded that there was no satisfactory evidence for genetic transmission of this disease. Steinberg et al.5 examined 464 patients with psoriasis. The disease was present among the patient's siblings 4 times as often when one parent had psoriasis as when neither parent was affected. Six per cent of the patient's parents had psoriasis. Because