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October 1961

Cellophane Tape Stripping: Effects on Guinea Pig Skin

Author Affiliations


From the Northwestern University Medical School, Department of Dermatology, Herbert Rattner, M.D., Chairman. This paper was awarded third prize in the Second Annual Essay Contest of the Chicago Dermatological Society.

Arch Dermatol. 1961;84(4):609-612. doi:10.1001/archderm.1961.01580160073012

Since the description in 1939 by Wolf1 of the method of removing the horny layer of the skin by repeated applications of cellophane tape this method has been frequently used in the study of human skin. Such problems as the number of cells and cell layers in the stratum corneum,2,3 the site of epidermal mitoses,4 melanocyte activity during epidermal regeneration,5 and the glycogen response in epidermal cells6,7 have been investigated by this technique.

These experiments have all been done in the human, and there do not seem to be any published reports of cellophane tape stripping done in animals. Pinkus, in unpublished work, stripped the hairless inner surface of the rabbit ear and the backs of newborn mice, but was unable to strip the keratin from the hairy skin of the rabbit or rat.8 The experiments reported here were all done in the guinea