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October 1961

Topical Methylprednisolone and Hydrocortisone Compared

Author Affiliations


From the Division of Dermatology, of the Department of Medicine, State University of New York, Downstate Medical Center.

Arch Dermatol. 1961;84(4):637-638. doi:10.1001/archderm.1961.01580160101018

A previous paper on the efficacy of methylprednisolone acetate in an ointment base reported good results in the treatment of dermatoses amenable to topical steroid therapy.1 Because the ointment vehicle was unsuitable for application to weeping lesions or to unexposed body areas, the author (Goldberg) selected only patients with subacute or chronic lesions on exposed surfaces.

Early clinical impressions concerning another methylprednisolone product have been favorable.2-4 In this product* methylprednisolone acetate is contained in a new watermiscible base, which in composition closely simulates the composition of normal skin lipids, allowing more physiological topical therapy.

Hydrocortisone serves as the reference standard for the evaluation of new topical steroid preparations. Accordingly, the present study was designed to compare the relative effectiveness of 0.25% methylprednisolone acetate and 1% hydrocortisone acetate in the new water-miscible base.

Materials and Methods  Four hundred seventy-seven patients with dermatoses expected to respond to topical steroid therapy