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October 1961

Griseofulvin (Grifulvin) in the Treatment of Violaceum Ringworm of the Scalp: Daily Versus Intermittent Dosage Schedules

Author Affiliations


Provided by McNeil Laboratories, Inc., Philadelphia.

Arch Dermatol. 1961;84(4):645-649. doi:10.1001/archderm.1961.01580160109021

Tinea violaceum of the scalp was until the past few years uncommon in the United States. Lately, as a result of the increased shifting of population, it has become more widely diversified. A violaceum epidemic in Willowbrook State School was reported by others1 in 1958. Since this epidemic spread rapidly and was resistant to x-ray and manual epilation as well as to all known types topical treatment, oral griseofulvin (Grifulvin*) was instituted in September, 1959.

Material and Methods  In this project 115 patients, 94 boys and 21 girls, with a ratio of approximately 4.5 boys to 1 girl, were enrolled. Their age ranged from 4 to 14 years and their ringworm had lasted from 1 month to 10 years. Almost all of the scalp lesions showed a high grade of inflammation or bacterial superinfection, and 3 patients presented also fungus infections of fingeror toenails. The 115 single and

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