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October 1961

Generalized Cytomegalic Inclusion DiseaseGeneral and Dermatologic Aspects with Report of a Case

Arch Dermatol. 1961;84(4):650-653. doi:10.1001/archderm.1961.01580160114022

In the past 10 years articles have been appearing regularly in the pediatric literature that describe a likely entity, now titled generalized cytomegalic inclusion disease, which seems to be a viral infection principally of infants.1-5 As in other systemic diseases, the skin may partake in the process and then may bear signs on or in it that are readily apparent either to the examining eye grossly or upon microscopy. Those signs are icterus and forms of contained hemorrhage (petechiae and purpura). The dermatologist who is knowledgeable of the condition may thus at times, in an appropriate case showing jaundice and petechiae or purpura, be able to suggest the possibility of generalized cytomegalic inclusion disease among other differential possibilities, and, if correct, the diagnosis may then be conclusively established by more or less simple laboratory procedures, especially search for characteristic inclusion bodies within epithelial cells found in urine sediment.


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