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October 1961


Arch Dermatol. 1961;84(4):676. doi:10.1001/archderm.1961.01580160140033

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The following additional material has been submitted by the authors of the article entitled, ``Rhinoscleroma,'' which appeared in the July issue of the Archives, pages 55-62.

COMMENT CONTINUED  At the end of 4 weeks cultures taken from the nasal lesion were repeatedly negative for Klebsiella rhinoscleromatis. The lesion regressed slightly in size but then reached a point where no further improvement occurred. Repeat biopsies revealed numerous small cysts in the cutis surrounded by a granulomatous reaction consisting of plasma cells, histiocytes, giant cells, and a few Russell bodies. No Mikulicz cells containing bacteria were seen.The mucosal ulcerations healed completely.The antibiotic was continued for another 4 weeks but no further evidence of shrinkage of the lesion occurred. The disease was considered arrested, but it is evident that with large lesions one cannot expect much cosmetic improvement with the antibiotics alone. The necessity of early diagnosis is therefore, most important.

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