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October 1961


Arch Dermatol. 1961;84(4):684-689. doi:10.1001/archderm.1961.01580160148040

Dermatitis Herpetiformis. Presented by Dr. Herbert Mescon.  A white housewife, aged 36, is presented from the Massachusetts Memorial Hospitals with an eruption of 3 years' duration.In October, 1957, when the patient was in the first trimester of a pregnancy, an intensely pruritic vesicular eruption appeared on both legs. It healed spontaneously within 2-3 weeks, but shortly thereafter recurred, with formation of pustules and crusts. As pregnancy progressed the dermatosis waxed and waned. It involuted completely one week prior to parturition but recurred 1 week postpartum, involving also the ears, scalp, breasts, back, and ankles. The eruption persisted more or less unchanged for several months, despite treatment with various antibiotics. In November, 1958, administration of sulfapyridine was begun (3.0 gm. daily), and all lesions disappeared within one week. The patient has remained on sulfapyridine therapy continuously for the past 2 years. The minimum daily dose required to suppress the disease

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