Amyloidosis of the skin is classified into the following 4 main groups: (1) primary systemic amyloidosis, systematized amyloidosis1; (2) secondary systemic amyloidosis, generalized amyloidosis; (3) primary localized amyloidosis, lichen amyloidosis, or amyloidosis localis cutis nodularis et disseminata,2-4 and (4) secondary localized amyloidosis ("seniles Amyloid," Freudenthal5).
In primary systemic amyloidosis, the parenchyma of the organs is largely spared; blood vessels, connective tissues, and muscles are the main site of involvement. This type of amyloidosis is often accompanied with multiple myeloma, Bence Jones proteinuria, and plasmocytoma.
Secondary systemic amyloidosis occurs in chronic diseases such as tuberculosis, leprosy, malaria, syphilis, osteomyelitis, and so on. Amyloid deposits are found in the parenchymatous organs, especially in the liver, kidney, spleen, and adrenals. In secondary localized amyloidosis, amyloid deposits are found in senile and pigmented verrucae, keratomas, epitheliomas, and cylindromas.
Primary localized amyloidosis has also been called lichen amyloidosis. It is a very
ANEKOJI K, IRISAWA K. Five Cases of Lichen Amyloidosis. Arch Dermatol. 1961;84(5):759–761. doi:10.1001/archderm.1961.01580170053007
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