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November 1961

Solitary Mastocytosis (Urticaria Pigmentosa)

Author Affiliations


From the Armed Forces Institute of Pathology.

Fellow in Dermal Pathology (Captain Johnson); Chief, Department of Pathology, and Chief, Skin and Gastrointestinal Branch (Dr. Helwig).

Arch Dermatol. 1961;84(5):806-815. doi:10.1001/archderm.1961.01580170100014

Mastocytosis has been studied vigorously from the clinical and physiological aspects during the past decade. This renewed interest has been due to the discovery that mastocytosis may occur as a systemic disease and to an increased knowledge of the biochemistry and physiology of the mast cell. Most of the recent reports have emphasized the patient with systemic involvement. This article deals with the other end of the clinical spectrum and includes the first report of solitary mastocytosis occurring in adults. A study of 14 patients with solitary mastocytosis was undertaken to determine the relative incidence, clinical course, and histopathological and histochemical characteristics.

The first example of mastocytosis occurring as a single lesion was recorded in 1933, when Gross1 presented a 5-month-old boy with a brownish nodule on the thigh to the New York Dermatological Society. Other cases have been reported by Cuilleret2 in 1935, Costello3 in 1948,