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November 1961


Arch Dermatol. 1961;84(5):868-873. doi:10.1001/archderm.1961.01580170162025

Diagnosis: Darier's Disease. Presented by Dr. S. M. Peck. 

History.—  A 41-year-old female. Skin eruption of about 35 years' duration. This patient has been under observation continuously since 1942. She has always noted that exposure to strong sunlight would cause a flare of her skin eruption on exposed areas. In 1952, after a summer vacation, there was a marked exacerbation of lesions with appearance on the face suggestive of L.E.

Family History.—  A niece also had Darier's disease.

Laboratory Findings.—  Essentially normal including blood cholesterol, blood sugar, etc. Vitamin A levels taken when she was first seen with the method then available showed inadequate response to ingestion of vitamin A in fairly large doses. Skin biopsy was compatible with the diagnosis of Darier's disease.

Clinical Course.—  She has been under continuous vitamin A therapy in doses of 150,000 units a day per os, and at times this had to be

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