Diagnosis: Darier's Disease. Presented by Dr. S. M. Peck.
A 41-year-old female. Skin eruption of about 35 years' duration. This patient has been under observation continuously since 1942. She has always noted that exposure to strong sunlight would cause a flare of her skin eruption on exposed areas. In 1952, after a summer vacation, there was a marked exacerbation of lesions with appearance on the face suggestive of L.E.
A niece also had Darier's disease.
Essentially normal including blood cholesterol, blood sugar, etc. Vitamin A levels taken when she was first seen with the method then available showed inadequate response to ingestion of vitamin A in fairly large doses. Skin biopsy was compatible with the diagnosis of Darier's disease.
She has been under continuous vitamin A therapy in doses of 150,000 units a day per os, and at times this had to be
Dougherty J, Costello MJ. MANHATTAN DERMATOLOGICAL SOCIETY. Arch Dermatol. 1961;84(5):868–873. doi:10.1001/archderm.1961.01580170162025
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