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December 1961

Monoamine Oxidase and Catechol O-Methyl Transferase Inhibitors: Effect of Intradermal Injection on Exogenous and Endogenous Norepinephrine

Author Affiliations


Assistant Clinical Professor of Dermatology (Dr. DeOreo); Director of Dermatology (Dr. Stoughton), Western Reserve University.

Arch Dermatol. 1961;84(6):972-979. doi:10.1001/archderm.1961.01580180088014

Introduction  In a previous paper we reported on the physiologic effect of a variety of norepinephrine derivatives (catecholamines) introduced into normal and diseased skin.2 Small differences in the chemical structure of these closely related compounds resulted in vastly different physiologic reactions.This communication concerns an effort to study some of the biologic mechanisms in human skin which participate in the metabolic inactivation of exogenous norepinephrine (see Fig. 1). Attempts to elicit evidence for the presence of endogenous catechol sympathomimetic amines will also be reported.In a search of the literature we were unable to find direct evidence which would definitely support the idea that norepinephrine is present in human skin. It is generally assumed that this physiologic metabolite is present in human skin.3 Recent workers, using histochemical and electron microscope techniques, have found indirect evidence of the presence of epinephrine-like substances,4,5 but there is still no