Mixed tumors of skin have been regarded by surgeons, dermatologists, and pathologists as intriguing curiosities for many years. Nasse is generally regarded as having described the first case in 1892.1 Since that time there have been many sporadic reports. Lennox et al.2 and Greeley et al.3 have published extensive review articles. Stout4 collected a large series and reported one case which he regarded as histologically malignant. Histochemical observations have recently been made by Laffargue.5 In spite of the fact that there are now over 100 cases of mixed tumors of skin reported in the world's literature, there have been no attempts to further delineate the origin of these neoplasms other than to assume sweat-gland genesis. That a more thorough evaluation of these tumors has not been made for over 60 years is understandable for 2 reasons: first, series of 2 or more cases have been
HEADINGTON JT. Mixed Tumors of Skin: Eccrine and Apocrine Types. Arch Dermatol. 1961;84(6):989–996. doi:10.1001/archderm.1961.01580180105016
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