A previous study of the usefulness of triamcinolone acetonide (Kenalog) in the treatment of acute and chronic lesions of the oral mucous membranes has been reported.*
After considerable experience with triamcinolone acetonide in Orabase (an adhesive paste vehicle), it became evident that although this formulation was effective in treating lesions up to 1 cc. in diameter, many patients found it difficult to spread the paste material evenly or to apply it as a thin film over larger lesions, particularly those in certain difficult to reach oral sites or those in almost totally inaccessible regions such as the uvula and adjacent areas, the anterior fauces, and the base of the tongue.
It was for these reasons that we investigated the possibilities of using a powder adhesive formulation (rather than a paste vehicle) of triamcinolone acetonide in the treatment of similar and additional lesions of the oral cavity.
Orahesive, a name applied
ZEGARELLI EV, KUTSCHER AH, SILVERS HF. Triamcinolone Acetonide in the Treatment of Oral Mucous Membrane Lesions: II. Continued Studies Using a Powder Adhesive Vehicle. Arch Dermatol. 1961;84(6):1035–1036. doi:10.1001/archderm.1961.01580180151029
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