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February 1962

Tuberous Sclerosis: Special Reference to the Microscopic Alterations in the Cutaneous Hamartomas

Author Affiliations


An uncommitted financial grant was given by Dr. Carl Herzog of Duke Laboratories to assist in defraying the expense involved in this study.

Arch Dermatol. 1962;85(2):209-226. doi:10.1001/archderm.1962.01590020049006

Tuberous sclerosis is a disease entity with protean manifestations, reported as being present in every organ and almost every structure of the body. It is familial and hereditary.

The skin lesions are not primarily problems of skin therapy. Gratification must be derived from making a diagnosis in the incomplete or forme fruste case in practice, without the classical triad of mental deficiency, epilepsy, and adenoma sebaceum. It is this type of case in which recommendations regarding marriage and reproduction are especially important in a condition unfamiliar to most physicians.

Historically the names of von Recklinghausen,1 who first described brain and heart lesions; Bourneville,2 who elaborated the brain findings; Pringle,3 whose name is attached to the facial lesions; Hallopeau-Leredde,4 who first described shagreen patches on the back; Sherlock,5 who coined the term ``epiloia,'' and Van der Hoeve,6 who first described the eye findings are all