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February 1962

The Biology of Experimental Human Cutaneous Moniliasis (Candida Albicans)

Author Affiliations


From the Department of Dermatology, University of Pennsylvania School of Medicine.

Arch Dermatol. 1962;85(2):233-257. doi:10.1001/archderm.1962.01590020073009

There has been no want of zeal in writing about moniliasis. Physicians seem endlessly fascinated by this disease and have constructed a mountainous literature as a monument to their interest. One would be greatly deceived if he were to think that this literary effusion signified a near complete knowledge of the disease process. On the contrary, there is a great lack of information on the dynamics of infection, the host-parasite relationship, and even so simple a thing as the histopathology. Current concepts derive almost entirely from gross clinical observation. Keen observation alone is insufficient to penetrate deeply into the mystery of the disease process and, indeed, has not even established firm diagnostic rules. In trying to evaluate the many things that have been said about moniliasis, one is plagued by doubts that the disease was correctly labeled in the first place. Certain expressions of the disease are unmistakable, but what