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Article
February 1962

SUCCESSFUL TREATMENT OF LEINER'S DISEASE WITH FLUOCINOLONE ACETONIDE

Author Affiliations

69-40 108th St. Forest Hills 75, N.Y.

Arch Dermatol. 1962;85(2):284. doi:10.1001/archderm.1962.01590020124021

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Abstract

To the Editor:—  In the January, 1961, issue of the Archives of Dermatology, Dr. Harry Robinson, Jr., reported on a series of cases treated with fluocinolone acetonide. As a corollary to that article, this writer would like to bring to the attention of your readers a case of Leiner's disease (desquamative erythroderma of infants, generalized seborrheic dermatitis) that was resistant to many topical preparations, including a variety of steroids, but responded dramatically to fluocinolone acetonide (Synalar; Syntex Laboratories).A 4-1b., 7 month, premature male infant developed a generalized erythematous and scaly eruption that spared few areas of the body. The skin was very oily, and considerable secondary lymphadenopathy was present. In addition, the child had a poor appetite and was extremely irritable. The following topical preparations were used unsuccessfully: combined sulfur and salicylic acid, Tarbonis (5% coal tar extract in a hydrophilic base), Cor-Tar-Quin (hydrocortisone, liquid carbonis detergens, and diiodohydroxy-quinoline),

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