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March 1962

WBC Skin and L.E. Cell Tests in Systemic Lupus Erythematosus

Author Affiliations


From the Department of Dermatology of the New York University School of Medicine and the Skin and Cancer Unit of University Hospital.

Arch Dermatol. 1962;85(3):374-377. doi:10.1001/archderm.1962.01590030072009

Introduction  Friedman et al.1 have recently described a new reaction pattern associated with systemic lupus erythematosus. It consists of an abnormal response to the intradermal injection of autologous and homologous white blood cells (WBC). These findings have been confirmed by Bennett and Holley2 using homologous white blood cells and in our department by Tromovitch and March3 who used autologous white blood cells in skin tests of 110 subjects including patients with various phases of lupus erythematosus and with blood dyscrasias, atopy, and miscellaneous skin diseases, as well as in control persons.In this report we present a case of systemic lupus erythematosus in which it was possible to correlate the results of WBC skin tests and of L.E. cell preparations with the clinical activity of the disease.

Report of a Case  A 28-year-old white single woman was admitted to University Hospital for the first time in August,