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March 1962

Familial Lupus Erythematosus: Discoid Lupus Erythematosus in Identical Twin Females

Author Affiliations


Arch Dermatol. 1962;85(3):394-396. doi:10.1001/archderm.1962.01590030092012

The familial incidence of lupus erythematosus has been recognized for many years, for in 1901 Rona21 described the condition in a brother and sister. In 1903 Sequeira1 presented 2 families each with 2 sisters with lupus erythematosus. Legobbe23 in 1937 was impressed by the finding of systemic lupus erythematosus in 8 members of one family and in 4 members of another family. In recent years the occurrence of 2 or more cases in one family has been reported with increasing frequency; however, lupus erythematosus in identical twins is rare. Von Gruenhagen5 reported the occurrence of the discoid type, and Davis and Gutridge3 plus Wagenhals and Burgeson13 published cases of fatal systemic lupus erythematosus in identical twin sisters.

Bridge and Foley22 demonstrated that transplacental passage of the lupus erythematosus factor can occur. These authors found L.E. cells in the mother, in the cord blood,