Although smallpox has been found in individuals with a vaccination "take" in activity, it seems that simultaneous infection by vaccinia and variola viruses in an eczematous person has not been reported. This paper presents clinical and virological observations made in an eczematous infant who was vaccinated too late to prevent smallpox.
Report of a Case
A Negro girl aged 6 months was admitted to the Isolation Hospital "Emílio Ribas" at the same time as her mother, who was nursing her. The mother presented a smallpox eruption, and the infant was vaccinated on admission and on the next day when 2 insertions were made. All 3 inoculations "took," and soon numerous pocks appeared on the face and some on the neck. According to her mother, the infant was suffering from eczema of the cheeks, and it was on these patches that pocks preferentially appeared becoming pustules, some of which
RABELLO SI, ANGULO JJ, SESSO J. Simultaneous Vaccinia and Variola in an Eczematous Infant. Arch Dermatol. 1962;85(3):405–406. doi:10.1001/archderm.1962.01590030103016
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