During the past several years there has been a concentrated attack upon the problem of divorcing the anti-inflammatory effect of systemic corticosteroids from the sequelae.1-3 With the advent of prednisone, the sequelae associated with water and sodium retention and potassium loss have been pretty well eliminated. There remained, however, the major sequelae due probably to the antianabolic effects: steroid-induced peptic ulcer, osteoporosis, muscle wasting, steroid-induced or steroid-exaggerated diabetes mellitus, plus a host of relatively infrequent sequelae of varying importance involving the skin and its adnexae, the eye, the psyche, blood vessels, and the immunologic apparratus.4-9 The newer corticosteroids have had little or no effect on the incidence of these sequelae. As yet it has been impossible to separate completely the anti-inflammatory effects of corticosteroid therapy from most of these sequelae.4,6-8,12 It is doubtful that this will be accomplished, since it appears probable that any attempt to
STRITZLER C, FRANK L, REIN R. Paramethasone, a New Corticosteroid, in Selected Dermatoses: Preliminary Report. Arch Dermatol. 1962;85(4):505–509. doi:10.1001/archderm.1962.01590040069010
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