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Original Articles
April 1962

Oxytalan-Fibers—Dermal Fibromas and Giant-Cell Tendon Sheath Tumors

Author Affiliations

BOSTON; LA JOLLA, CALIF.
From the Department of Pathology, Massachusetts Memorial Hospitals, Boston, and Scripps Memorial Hospital, La Jolla, Calif.

Arch Dermatol. 1962;85(4):527-529. doi:10.1001/archderm.1962.01590040091014
Abstract

A newly identified connective-tissue fiber, in acknowledgement of its resistance to acid hydrolysis, has been named the oxytalan fiber.1 As previously reported, fibers with this characteristic have been identified particularly in structures subjected to mechanical stress, such as tendons, ligaments, adventitia of blood vessels, epineurium, perineurium, and the connective-tissue sheaths that surround the skin appendages.2 Although not found in the connective tissue of the normal dermis,1 they occur as a prominent component of the dermal-epidermal junction in abnormal skin.3

The search for oxytalan fibers in pathological states so far has been directed to their identification in dental granulomas, radicular cysts,4 and sclerosing hemangiomas.5 Oxytalan fibers have now been further investigated in giant-cell tumors of tendon sheath, dermal fibromas, and keloids, all lesions the origin of which is still somewhat controversial.

Materials and Methods  Our study is based on 20 giant-cell tumors of tendon sheaths,

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