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May 1962

Extramammary Paget's Disease: A Report of Two Cases

Author Affiliations


From Department of Dermatology, Medical College of Virginia.

Arch Dermatol. 1962;85(5):600-613. doi:10.1001/archderm.1962.01590050030006

The initial case report in the United States of extramammary Paget's disease, by Hartzell, foretold the confusion and controversy which was to follow. Hartzell's1 case was not one of the disease, and a number of similar papers subsequently appeared in the literature. Weiner,2 Pinkus,3 and others have contributed much to clarify the subject both clinically and pathologically.

The purpose of this paper is to present the clinical appearance, the pathology and therapy, of one mild and one fatal case of extramammary Paget's disease. The autopsy findings which revealed widespread metastases in the latter case will be presented, and the histogenesis of the Paget cell will be discussed.

Report of Cases 

Case 1.—  A white male, age 75, was seen on Aug. 18, 1959, complaining of an eruption of one year's duration in the groin. On examination there was an erythematous exudative plaque measuring 2×3 cm. located in the