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May 1962

Psoriasis (Immunological Studies)

Author Affiliations


From the Department of Dermatology, Wayne State University College of Medicine, Detroit, and Allergy Service, Research Service, Veterans Administration Hospital, Dearborn, Mich.

Arch Dermatol. 1962;85(5):614-616. doi:10.1001/archderm.1962.01590050044007

Immunologic mechanisms in psoriasis have been postulated previously,1 but convincing experimental evidence for such mechanisms has not been shown. Aswaq, Farber, Moreci, and Raffel2 demonstrated delayed type skin reactions, using a modified passive cutaneous anaphylaxis technique5 with psoriatic plaque homogenate as antigen and human psoriatic serum as antibody.

Our present study was designed to explore such possible antigen-antibody mechanisms and, if successful, to expand such studies to other skin disorders thought to be subject to autoimmune mechanisms.

Materials and Methods  Albino male guinea pigs, weighing 250-750 gm., were used. The abdomen or back of each guinea pig was shaved 12-24 hr. prior to the intradermal injection of psoriatic and/or normal human control serum. The patients were divided into 2 groups. Ten patients with psoriasis were in the study group. They had no neoplastic, infectious, or metabolic disease (except for one patient with gout). The control patients were