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May 1962

Further Studies of Immunologic Reactions in Psoriasis

Author Affiliations


Department of Dermatology (Dr. Moreci and Dr. Farber); Department of Medical Microbiology (Dr. Raffel), Stanford University School of Medicine.

Arch Dermatol. 1962;85(5):617-622. doi:10.1001/archderm.1962.01590050047008

It has been suggested that the pathogenesis of psoriasis may be related to immunological processes.1-3 In a recent study, Aswaq et al. postulated that if autoimmune or allergic mechanisms were operative, the sera of psoriatic patients might contain antibodies directed against their own skin.4 Accordingly, this question was investigated using the highly sensitive passive cutaneous anaphylactic technique to detect any antigen-antibody interaction.5,6 Results of this study indicated that specific, apparently immunologic reactions could be evoked in guinea pigs with serum and plaque tissue provided by patients with psoriasis. In view of these observations, it was speculated that this disease may depend upon an autoimmune process; however, it was clearly stated that the available data did not provide firm objective evidence for this possibility.

In the course of further work on the immunology of psoriasis, results were obtained which conflicted with those reported by Aswaq et al.

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