Evaluation of new agents in the treatment of acne and psoriasis is fraught with difficulty. This is evidenced by the number of new medicaments which have been introduced with enthusiasm to be cast aside later as valueless. Two factors have been mainly responsible: first, normal fluctuation in severity of these particular disorders and, second, lack of adequate controls in most investigations.
During recent years γ-globulin has been utilized by several investigators in the management of acne. Shaffer and co-workers1 reported on 4 patients with severe pustular and cystic acne who had been resistant to conventional therapy; after 2 injections of 10 cc. of poliomyelitis immune globulin in successive weeks there was temporary improvement in 2 cases and no change in the other 2. Sutton and Asel2 used γ-globulin in dosage of 2 cc. at approximately weekly intervals, in addition to standard therapy, for 19 patients with acne. Results
KERN AB. Gamma-Globulin in Treatment of Acne and Psoriasis. Arch Dermatol. 1962;85(5):623–624. doi:10.1001/archderm.1962.01590050053009
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