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May 1962


Arch Dermatol. 1962;85(5):667-685. doi:10.1001/archderm.1962.01590050097025

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Case 1: Chronic, Discoid Lupus Erythematosus: Melanosis Secondary to Antimalarial Therapy. 

History.—  This 53-year-old farmer, in good general health, developed lesions of discoid lupus erythematosus on the cheeks, beginning on the left cheek in 1955 and on the right in 1958. Treatment was begun here in January, 1959, by means of chloroquine, but was discontinued after 3 months because of ocular symptoms of haziness and difficulty in accommodation. Camoquin was substituted and was well tolerated, the lesions of lupus subsiding but never clearing entirely. In March, 1961, a diffuse gray pigmentation became evident over the lower legs and palate.

Biopsies.—  A biopsy of the right cheek showed senile skin plus probable lupus erythematosus. A biopsy of the right leg showed melanin pigmentation of the dermis.

Case 2: Chronic Discoid Lupus Erythematosus. Hodgkin's Disease. Carcinoma of the Cervix. 

History.—  This 58-year-old housewife has had lesions of discoid lupus erythematosus for

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