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June 1962

Lack of Passive Cutaneous Anaphylaxis in Psoriasis

Author Affiliations


From the Departments of Dermatology and Pathology, New York University Medical Center.

New York City Health Research Council Investigator (Dr. Ovary). This work was supported in part by the Health Research Council of the City of New York under contract No. I-140 and in part by grants from the United States Public Health Service (National Institute of Allergy and Infectious Diseases) No. E-3075 and No. E-1361 (C4 and C5).

Arch Dermatol. 1962;85(6):716-719. doi:10.1001/archderm.1962.01590060026004

Introduction  Passive cutaneous anaphylaxis has been demonstrated to be an extremely sensitive method for the demonstration of antigen-antibody reactions of the immediate type.1-3 The most commonly used form of this testing procedure is based on the localization of a dye at the site of an intradermal injection of antibody. Antigen necessary to elicit the reaction is administered intravenously along with Evans blue solution several hours after the intradermal injection of antibody. Visible skin reactions appear within minutes at the sites of antigen-antibody combination. These reactions can generally be more accurately assessed by measurements on the internal skin surface.Recently, a modification of this procedure has been reported capable of producing reactions when psoriatic serum was injected intradermally and after a latent period psoriatic skin homogenates were injected with dye intravenously, suggesting an immune mechanism to be operative in psoriasis.4The study to be reported here was undertaken in