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Article
June 1962

Intradermal Hyaluronidase Corticosteroid Therapy

Author Affiliations

JOHNSTOWN, PA.

Arch Dermatol. 1962;85(6):735-736. doi:10.1001/archderm.1962.01590060045008
Abstract

The recent introduction of intralesional steroid injections in the treatment of chronic miscellaneous dermatoses represents a definite advance in dermatologic therapy. Reports of this modality are not numerous, but there is general agreement concerning its efficacy.1,2 The advantages of this procedure are based on the fact that instead of the indirect oral route which requires alimentation and metabolization of the drug, the steroid is deposited in the immediate site of the dermatitis, thus effecting a direct tissue response. Generalized untoward reactions are, therefore, extremely rare, and frequently the therapeutic response is prolonged in contrast to that frequently observed after cessation of oral steroid administration. The method is not applicable to the treatment of extensive dermatoses, since only small areas can be treated at one time. There is little pain associated with the injections, though this can be decreased by the addition of procaine to the mixture and by spraying

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