This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables.
Letterer-Siwe Disease (Malignant, Nonlipid Reticuloendotheliosis). Presented by Dr. George C. Anderews.
The patients were 8-month-old white male infants, identical twins. At the age of 4 months, both developed a skin eruption which persisted in spite of local use of steroids. There were involvement of the scalp consisting of a dry, scaly eruption which looked like "cradle cap" and also involvement of the mouth.They developed "ear infections" which cleared up after a while on antibiotics.
On physical examination both infants present more or less the same clinical picture. The scalp is involved with a yellowish-brown crust which simulates seborrheic dermatitis. The skin, especially trunk and abdomen, presents a reddish-brown to orange-colored papular scaly eruption. Some of the papules look hemorrhagic; others are like xanthoma. Some are petechiae. There are small ulcerations in the oral mucosa.There is no lymphadenopathy, and spleen and liver cannot be palpated.
Barker LP, Sachs W. NEW YORK DERMATOLOGICAL SOCIETY. Arch Dermatol. 1962;85(6):812–820. doi:10.1001/archderm.1962.01590060122024
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: