[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address 35.153.39.7. Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Article
June 1962

NEW YORK DERMATOLOGICAL SOCIETY

Arch Dermatol. 1962;85(6):812-820. doi:10.1001/archderm.1962.01590060122024

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables.

Abstract

Letterer-Siwe Disease (Malignant, Nonlipid Reticuloendotheliosis). Presented by Dr. George C. Anderews. 

History.—  The patients were 8-month-old white male infants, identical twins. At the age of 4 months, both developed a skin eruption which persisted in spite of local use of steroids. There were involvement of the scalp consisting of a dry, scaly eruption which looked like "cradle cap" and also involvement of the mouth.They developed "ear infections" which cleared up after a while on antibiotics.

Physical Examination.—  On physical examination both infants present more or less the same clinical picture. The scalp is involved with a yellowish-brown crust which simulates seborrheic dermatitis. The skin, especially trunk and abdomen, presents a reddish-brown to orange-colored papular scaly eruption. Some of the papules look hemorrhagic; others are like xanthoma. Some are petechiae. There are small ulcerations in the oral mucosa.There is no lymphadenopathy, and spleen and liver cannot be palpated.

First Page Preview View Large
First page PDF preview
First page PDF preview
×