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July 1962

Aplasia Cutis Congenita

Author Affiliations


From the Dermatology Department of Cleveland Metropolitan General Hospital.

Arch Dermatol. 1962;86(1):54-57. doi:10.1001/archderm.1962.01590070060008

Congenital defect of the skin constitutes one of the rare and interesting anomalies peculiar to the newborn. Its extreme rarity, in comparison with the great frequency of minor aberrations such as disturbances of pigment, hair, glandular development, and vascular supply, can only mean that the natural, inherent factors at work in covering the body with some kind of an epithelial layer are far more ancient, fundamental, deepseated, tenacious, and stubborn than those influences which prescribe the finer details of that covering once it is established. Frank defects, absence of the skin, must invoke far more powerful, more incisive, genetic influences or have as etiology active trauma, physical violence, or other external forms of tissue destruction.1

A variety of physical and endogenous factors may lead to arrested development of the embryonic skin.2 There are many theories as to the cause, and no single one can explain all cases.3