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July 1962


Arch Dermatol. 1962;86(1):112-117. doi:10.1001/archderm.1962.01590070118032

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Epithelioma Adenoides Cysticum. Presented by Dr. Irving L. Schonberg and Dr. Jerome Z. Litt.  A 32-year-old Negro male first began to notic "tumors" on his face at the age of 14 or 15. These have become progressively larger and more numberous in the succeeding years. His father and paternal grandfather had similar conditions.Examination of the skin reveals numerous pearly, yellowish to yellowish-brown nodules, varying in size from matchhead to large pea-size, located over the entire face. Some of the lesions have telangiectatic blood vessels and are fairly well embedded in the skin, solid and painless to the touch.Biopsy: There are dilated spaces filled with keratin and surrounded by basal cells with slight attempt at maturation. The basal cell proliferation appears to be limited to hair follicles and forms small-to-large irregular clusters. Although there is some proliferation around the periphery by basal cells with a palisaded layer suggesting basal

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