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August 1962

Herpes Simplex Following Operation for Trigeminal Neuralgia: Further Futile Attempts to Modify, by the Local Use of an Iodophor and by the Systemic Use of ?-Globulin

Arch Dermatol. 1962;86(2):236. doi:10.1001/archderm.1962.01590080106017

In a prior communication1 we described our attempts to modify herpes simplex following the decompression operation2 on the fifth cranial nerve by using hydrocortisone ointments and bacterial ointments locally. In 148 patients, approximately one-third developed herpes, and we could not modify the attack rate by the use of the above agents. Since that time, 76 more patients have been operated on for tic douloureux using the same decompression or neurolysis type of procedure. Twenty-eight of these patients were painted with a 3% solution of an iodophor (Wescodyne) consisting of 7.75% polyethoxy polypropoxy ethanol-iodine complex; 3.75% nonylphenylether of propylene glycol-iodine complex; and 0.10% hydrogen chloride before and after operation twice daily. The use of this iodine complex did not modify the attack rate, as 12 of the 28 individuals developed florid herpes simplex.

In addition, 4 patients were given poliomyelitis immune globulin (human), Merck Sharpe & Dohme, 10 cc.