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October 1962

Oral Florid Papillomatosis: Clinical, Pathological and Electron Microscopic Observations

Author Affiliations


From the Departments of Dermatology and Pathology, University of Pittsburgh.

Arch Dermatol. 1962;86(4):480-492. doi:10.1001/archderm.1962.01590100094019

Squamous cell papillomas are common neoplasms of the skin and are not infrequently encountered in the mucous membrane of the oropharynx and larynx. Less frequent sites of involvement include the nose,1 trachea, and bronchi.2-4 Those occurring in the larynx in childhood have been inherently benign, often exhibiting regression of growth with the onset of puberty. On the other hand, the presence of such lesions in the adult have been considered to possess the potential for carcinomatous transformation, although documented examples of such an event are few.5-7

In the adult these papillomas are most commonly solitary and simple excision is usually unattended by recurrence or other sequelae. However, it is becoming more widely appreciated that the squamous cell papilloma in some instances may appear as multiple, confluent growths involving large areas of mucous membrane. Unlike the solitary variety, this form which one of us (Dr. Fisher) has previously