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October 1962

Subcutaneous Fat in Leukemia and Lymphoma

Author Affiliations


From the Department of Medicine, Veterans Administration Hospital.

Arch Dermatol. 1962;86(4):520-524. doi:10.1001/archderm.1962.01590100134025

Fat is a metabolically active, highly vascularized tissue which is considered by some investigators to be part of the histiocytic system with functions other than just fat storage.1,2 Thus, blood-forming function may be reestablished in adipose tissue under appropriate conditions.3 The potential for blood cell formation varies with the anatomical site of the adipose tissue and with the species of animal. Omentum and perirenal fat are common sites of extramedullary hematopoiesis under conditions of increased demand. In pathologic states, as in the leukemias and lymphomas, hematopoiesis may be found in all adipose tissue including pericardiac fat and skin.* Fat is also one of the major components of the bone marrow. Indeed, the areas of extramedullary hematopoiesis in adipose tissue bear such a striking resemblance to the marrow itself to suggest possibly a more than casual relationship between fat and blood cell formation, and further, that fat may

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