Three patients with porphyria hepatica are reported including I with the mixed type and 2 with porphyria cutanea tarda. The administration of chloroquine, in total doses ranging from 1 to 2.5 gm., resulted in an exacerbation of clinical symptoms by the third or fourth day, manifested by malaise, fever, tachycardia, and impaired liver function. In addition, a considerable disturbance of urinary porphyrins occurred, which was estimated by quantitative studies.
CRIPPS DJ, CURTIS AC. Toxic Effect of Chloroquine on Porphyria Hepatica. Arch Dermatol. 1962;86(5):575–581. doi:10.1001/archderm.1962.01590110011002
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