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November 1962

Toxic Effect of Chloroquine on Porphyria Hepatica

Author Affiliations


The Department of Dermatology, The University of Michigan.

Arch Dermatol. 1962;86(5):575-581. doi:10.1001/archderm.1962.01590110011002

Three patients with porphyria hepatica are reported including I with the mixed type and 2 with porphyria cutanea tarda. The administration of chloroquine, in total doses ranging from 1 to 2.5 gm., resulted in an exacerbation of clinical symptoms by the third or fourth day, manifested by malaise, fever, tachycardia, and impaired liver function. In addition, a considerable disturbance of urinary porphyrins occurred, which was estimated by quantitative studies.