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November 1962

Method for Comparing Percutaneous Absorption of Steroids

Arch Dermatol. 1962;86(5):608-610. doi:10.1001/archderm.1962.01590110044005

A simple method for assessing the percutaneous absorption of steroid preparations is suggested.

Using vasoconstriction as an index of absorption, occlusion of the skin surface with Saran Wrap results in a 100-fold difference in absorption over simple topical application.