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November 1962

Toxic Epidermal Necrolysis

Author Affiliations


Consultant Dermatologist to the Royal Victoria Hospital and the Royal Belfast Hospital for Sick Children.

Arch Dermatol. 1962;86(5):638-653. doi:10.1001/archderm.1962.01590110074011

Ten new cases of toxic epidermal necrolysis are recorded.

The series includes several young babies; I was aged only 2 weeks, and 3 children were under the age of I month.

One child had a second attack, and this was dramatically stopped by early administration of steroids.

One adult patient was seen, and after she became profoundly ill much hypertrophic scarring was left on several scattered areas.

The adult patient was given very large daily doses of steroid drugs about the third month of pregnancy. She eventually gave birth to a normal child after 37 weeks' pregnancy.

The most striking feature in all cases was pain and skin tenderness.

In most of the 10 cases the hairy parts of the body were not affected.

In only one case was drug sensitivity considered the likely cause. In several of the patients no drugs at all had ever been given.

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