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January 1963

Response of Psoriatic Lesions to Topical Fluocinolone Acetonide

Author Affiliations


Department of Dermatology, Tufts University School of Medicine and Department of Dermatology, Boston University School of Medicine.

Arch Dermatol. 1963;87(1):27-31. doi:10.1001/archderm.1963.01590130033007

This study consisted of an additional 6-10 month follow-up of 214 patients (previously reported on)1 with psoriasis treated with fluocinolone acetonide cream and occlusive dressings.

All but one of 102 patients with intertriginous involvement with psoriasis responded well to the topical use of fluocinolone acetonide without an occlusive dressing. They remained either free or nearly free of lesions by intermittent treatment.

Approximately one-third of the 116 patients with localized psoriasis treated with a moist occlusive dressing plus fluocinolone acetonide cream had no recurrence after cessation of treatment. All patients, but 2 responded to re-treatment and remained at least 80% clear on intermittent applications.

In 55 patients with widespread psoriasis who were treated with the corticosteroid cream and occlusive dressings also showed a good initial response. The prolonged effectiveness, however, was not as good as in the other 2 groups of patients.

Except for 2 patients with miliaria who developed psoriatic lesions at the site of the miliaria, all complications cleared on temporary interruption of treatment.

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