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January 1963

Malignant Papulosis of Skin and Cerebrum: A Syndrome of Vascular Thrombosis

Author Affiliations


Section of Dermatology (Drs. Winkelmann and Perry); Section of Neurology (Dr. Howard); Section of Neurologic Surgery (Dr. Miller); Mayo Clinic and Mayo Foundation.

Arch Dermatol. 1963;87(1):54-62. doi:10.1001/archderm.1963.01590130060011

Two cases of malignant atrophic papulosis of the skin are reported together with delineation of the neurologic syndromes produced in them by involvement of the central nervous system. The cutaneous and cerebral lesions were those of infarction produced by an endovasculitis. The electroencephalogram and examinations of cerebrospinal fluid were helpful in diagnosis. It is anticipated that involvement of other viscera will occur with the syndrome of malignant atrophic papulosis.

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