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January 1963

Effect of Vitamin A on Epithelial Cells of Skin: The Use of Vitamin A in the Treatment of Diseases Characterized by Abnormal Keratinization

Author Affiliations


From The Skin and Cancer Hospital of Philadelphia, Department of Dermatology, Temple University School of Medicine.

Arch Dermatol. 1963;87(1):63-80. doi:10.1001/archderm.1963.01590130069012

The present evaluation of the role of vitamin A in the treatment of skin diseases characterized by abnormal keratinization and the problem of its toxicity are the first phase of a study in depth of the modulating effect of vitamin A on epithelial cells of the skin in vivo and vitro. In this study, the clinical and histopathological effects of vitamin A on keratosis follicularis, ichthyosis, congenital ichthyosiform erythroderma, psoriasis, and pityriasis rubra pilaris were determined.

Christian Eijkman's discovery in 1897 of a factor in rice polishings which was essential for growth and development opened a new era in the understanding of the role of vitamins in the treatment and prevention of disease. Search for additional factors led to the discovery of vitamin A in 1913, but its chemical configuration was not known until 1931.1 The fact that vitamin A is an old story does not dim, but rather

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