The chancriform syndrome is the clinical picture to be expected if a fungus capable of causing a deep mycosis in normal individuals is acquired by direct cutaneous inoculation into a person not previously infected by that organism but who is capable of developing a high degree of immunologic resistance. Sporotrichosis in its usual form is the prototype of the chancriform stage in fungal diseases, but it also occurs occasionally in coccidioidomycosis, North American blastomycosis, histoplasmosis, and nocardiosis. In some of the remaining deep fungous infections it may also occur at times under special circumstances; in others it may never occur.
The chancriform syndrome indicates a degree of immunologic resistance sufficient to result either in complete spontaneous cure, or to furnish enough assistance so that any of several drugs can be successful, but which are ineffective in other more serious stages of the disease in which resistance is low or absent.
J. WALTER WILSON. Cutaneous (Chancriform) Syndrome in Deep Mycoses. Arch Dermatol. 1963;87(1):81–85. doi:10.1001/archderm.1963.01590130087013