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January 1963

Ankle Ulcer Sign of Werner's Syndrome

Author Affiliations


Department of Dermatology, University of Pennsylvania School of Medicine.

Arch Dermatol. 1963;87(1):86-88. doi:10.1001/archderm.1963.01590130092014

In 1934, Oppenheimer and Kugel1 distinguished the 2 conditions originally reported by Werner in 1904 and Rothmund in 1868 and established the criteria for the eponymic Werner's syndrome as we know it today. We are presenting another case of this rare disorder in which chromosomal studies were performed. The brother of the patient in question was briefly seen, but unfortunately could not be studied, although he also exhibited some classical signs of the same condition.

The fully developed syndrome creates a remarkably constant picture, although incomplete forms have been reported. Detailed listings of these changes can be found in most of the medical literature on Werner's syndrome.2 In brief, the usual changes of this particular form of progeria are (a) premature senility (premature baldness and gray hair; juvenile cataracts, arteriosclerosis); (b) scleroderma-like changes, clinically not histologically (atrophic skin and loss of subcutaneous tissue; circumscribed hyperkeratosis of soles; tightness

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