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February 1963


Arch Dermatol. 1963;87(2):272-278. doi:10.1001/archderm.1963.01590140134026

Pseudoacanthosis Nigricans; Mild Hyperadrenocorticism, Predominantly Hyperandrogenic. Presented by Dr. J. S. Strauss.

A woman aged 20 is presented from Lemuel Shattuck Hospital with a dermatosis involving the back of the neck, axillas, and inguinal and inframammary regions, which has been present for 12 years.

At the age of 8 the patient developed hyperpigmentation and thickening of the posterior nuchal skin folds, followed at puberty by similar but less marked changes in the axillas and the inguinal and inframammary regions. The lesions have undergone no essential alteration since puberty and are asymptomatic. At the age of 12 the patient noted hirsutism of the arms, legs and face, and at 13 she began daily beard shaving. She weighed 89 pounds at 6 years, and 225 pounds at 13. The menarche occurred in 1953 at the age of 12, with 3 periods that year and only 4 in the intervening years up to