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March 1963

Mechlorethamine Therapy for Systemic Lupus NephropathyAnalysis and Review of Ten Years' Experience and a Clinical Study of 211 Cases Including 81 Patients Treated With Mechlorethamine

Arch Dermatol. 1963;87(3):289-298. doi:10.1001/archderm.1963.01590150005001

A series of 211 patients with systemic lupus erythematosus (SLE) was presented, 84 of whom had initial renal involvement; 81 of 211 patients were treated with HN2; 130 of 211 patients were not treated with HN2 and tend to assume the role of a control group. Although it is difficult to draw any specific conclusions because of the wide range of variations in patients with SLE, there appears to be a definite and beneficial longterm effect from the use of HN2 in lupus erythematosus (LE) nephropathy.