[Skip to Navigation]
April 1963

Oral Florid Papillomatosis: Response to Aminopterin

Author Affiliations


From the Department of Dermatology, School of Medicine, University of Pennsylvania.

Arch Dermatol. 1963;87(4):478-480. doi:10.1001/archderm.1963.01590160070013

A case of oral florid papillomatosis greatly improved over a two-year period from periodic low doses of aminopterin, a folic acid antagonist. No systemic side-effects were observed, and the papillomatous growth, refractory to previous prolonged topical therapy, showed approximately 80% involution during the course of therapy. It is postulated that aminopterin was beneficial by inhibiting epithelial proliferation.

Add or change institution